Endocrine Abstracts

Case Report: A 42 year-old male, with a family history of phaeochromocytomas and paragangliomas, was diagnosed as a carrier of the succinate dehydrogenase subunit-B (SDHB) mutation. He was also diagnosed with macroprolactinoma and treated with cabergoline (currently 250 mcg weekly). A contrast CT chest scan, performed as part of the surveillance program for SDHB-associated tumours, revealed a small right lung lesion, which was found to be OctreoScanTM positive. The ...

Background: Cardiovascular stratification and prevention in type 2 diabetic patients represent a major public health preoccupation in order to reduce their mortality. Several methods of detecting atherosclerosis have been developed such as biomarkers. The aim of this study was to evaluate the association between B-type natriuretic peptide (BNP) and cardiovascular risk (CVR) in type 2 diabetic patients.Methods: We conducted a cross-sectional study in 71 t...

Despite being identified almost two decades ago, the biological roles for C-type natriuretic peptide (CNP) have remained poorly elucidated. Both CNP and GC-B are highly conserved from flies and fish to humans. Recent investigations involving the disruption of the CNP gene (Nppc) or that of its GC-B receptor (Npr2) implicate a role for CNP and GC-B in bone formation and growth. Intriguingly, CNP and GC-B knock-out mouse models also exhibited pituitary growth hormone deficiency....

Glucocorticoids (GC) are catabolic in skeletal muscle to provide nutrients during fasting or other stressors, including inhibiting insulin-mediated glucose uptake, protein synthesis, and mitochondrial function, while stimulating proteosomal breakdown of proteins. Published work in cultured myotubes required μM GC dosing to see these effects. We found GCs to show low nM activity in myotubes by using a more physiologically relevant setting, including nutrient deprivation an...

Introduction: The visceral adipose tissue-derived serine protease inhibitor (vaspin), a novel adipocytokine, has been widely reported to be associated with obesity and insulin resistance. Obesity induced chronic inflammatory process plays a pivotal role in insulin resistance and is characterized by the activation of NF-κB pathway and its target genes. The present study aims to investigate the effects of vaspin on NF-κB pathway and its target genes in basal and TNF-&#...

Anti-thyroid antibody (ATA) positivity affects 1 out of 9 women in childbearing age and presents a significant risk for infertility. Emerging evidence indicates that alterations in the B cell receptor induced calcium (Ca2+) signaling could be key in the development of autoimmunity. We aimed to investigate the Ca2+ flux response of B lymphocyte subsets to BCR stimulation in Hashimoto’s thyroiditis and related infertility. We collected peripheral blood samples from ATA+, in...

The G protein coupled receptor of obestatin GPR39 is expressed in pituitary and gonads, indicating its possible role in regulation of pituitary and testicular function. The present study examined a possible association of obestatin with LH, FSH, testosterone, and inhibin B at puberty. Blood samples were collected from 10 to 20 years old boys (n=557) and concentrations of obestatin, LH, FSH, testosterone, and inhibib B were determined using specific ELISA. Data were an...

Objectives: To study the direct effects of fatty acids (FA) and the involvement of the TLR-4/NFκB pathway with respect to the secretion of adipokines and chemokines from adipocytes.Research design and methods: 3T3-L1 adipocytes were stimulated with increasing doses of FA. The secretion of adiponectin, resistin and MCP-1 was measured by ELISA. NFκB p65 nuclear translocation and TLR-4 expression were investigated by Western blot analysis. NF&#954...

Introduction: The diffuse large B-cell lymphoma (DLBCL) is known as one of the most common lymphoma worldwide with the prevalence of 25 % of all of non-Hodgkin lymphoma cases [1], but it is very rearly observed in thyroid. Around 30 % of Clinical cases of the DLBCL appear from extranodal organs, the prognosis depends on the site of origin [2].Case: A 18-year-old man was admitted to endocrinologist, complaining with a palpable nodule in the front neck for...

Objectives: The Clinical Activity Score (CAS) is used to measure and classify Graves orbitopathy activity (GO). However, CAS is partly subjective, and the evaluation of its components is binary. As CAS is known to be correlated with TSH receptor antibodies (TRAb), we wanted to evaluate other immunological parameters in the peripheral blood as markers of GO activity.Methods: The study included 32 patients (19 females, 13 males). CAS was evaluated by a sin...